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Defending Against Dengue Fever: Exploring the Quest for a Dengue Vaccine

Updated: Mar 15

Dengue fever vaccination

Dengue fever, a mosquito-borne viral illness, poses a significant public health challenge, particularly in tropical and subtropical regions around the world. With millions of cases reported annually, and no specific treatment available, the development of a dengue vaccine has been a priority for researchers and healthcare professionals alike. Let's delve into the current state of affairs regarding the quest for a dengue vaccine.

Understanding Dengue Fever

Dengue fever is caused by the dengue virus, which is transmitted to humans primarily through the bite of infected Aedes mosquitoes. Symptoms of dengue fever can range from mild, flu-like illness to severe and potentially fatal dengue haemorrhagic fever or dengue shock syndrome. The absence of a specific antiviral treatment makes prevention through vaccination a critical strategy in combating the disease.

The Pursuit of a Dengue Vaccine

Over the years, researchers have made significant strides in developing a vaccine against dengue fever. One of the most promising candidates is the Qdenga® vaccine. Qdenga® is a live attenuated vaccine designed to provide protection against all four serotypes of the dengue virus.

Who Should Get Vaccinated?

The World Health Organization (WHO) recommends vaccination against dengue fever in endemic regions for individuals aged 9 to 45 years. It's particularly crucial for individuals living in or traveling to areas with a high risk of dengue transmission to consider vaccination.

Benefits of Vaccination

  1. Prevention of Infection: The primary benefit of the dengue vaccine is its ability to prevent dengue fever, reducing the risk of illness and its associated complications.

  2. Reduced Disease Burden: By vaccinating individuals in endemic regions, the burden of dengue fever on healthcare systems and communities can be significantly reduced.

  3. Community Protection: Vaccination not only protects vaccinated individuals but also contributes to herd immunity, reducing the overall transmission of the dengue virus within populations.

Safety and Efficacy

The Qdenga® vaccine has been shown to be safe and efficacious in clinical trials, providing significant protection against severe dengue in vaccinated individuals. However, like any vaccine, Qdenga® may cause mild side effects such as headache, muscle pain, and fever.


The development of a dengue vaccine represents a significant advancement in the fight against dengue fever, a disease that affects millions of people worldwide each year. While challenges remain, including ensuring access to vaccination in endemic regions and ongoing research to improve vaccine efficacy, the availability of the Qdenga® vaccine marks a crucial milestone in dengue prevention efforts.

If you reside in or plan to travel to an area where dengue fever is prevalent, consider discussing vaccination with the Oxford Travel Vaccination Centre . Prevention through vaccination, combined with mosquito control measures, remains our best defence against dengue fever. Together, we can work towards a future where dengue is no longer a threat to global health and well-being.

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